MDSure

1 Department of Radiation Oncology, Kimmel Cancer Center & Jefferson Medical College of ThomasJefferson University, Philadelphia, PA, USA.

2 Department of Surgery, Kimmel Cancer Center & Jefferson Medical College of Thomas Jefferson University,Philadelphia, PA, USA.

3 Myrna Brind Center of Integrative Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA*Author for correspondence: Tel.: +1 215 503 0554  n Fax: +1 215 955 0412n nicole.simone@jeffersonhospital.org

 

As the link between obesity and metabolic syndrome and cancer becomesclearer, the need to determine the optimal way to incorporate dietarymanipulation in the treatment of cancer patients becomes increasingly important.Metabolic-based therapies, such as caloric restriction, intermittent fasting anda ketogenic diet, have the ability to decrease the incidence of spontaneoustumors and slow the growth of primary tumors, and may have an effect on distantmetastases in animal models. Despite the abundance of preclinical datademonstrating the benefit of dietary modification for cancer, to date there arefew clinical trials targeting diet as an intervention for cancer patients. Wehypothesize that this may be due, in part, to the fact that several different typesof diet modification exist with no clear recommendations regarding the optimalmethod. This article will delineate three commonly used methods of dietarymanipulation to assess the potential of each as a regimen for cancer therapy.

 

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